InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FNIP1

Summary

InnateDB Protein

IDBP-40480.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FNIP1

Protein Name

folliculin interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000309266

InnateDB Gene

IDBG-281600 (FNIP1)

Protein Structure

UniProt Annotation

Function

May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. {ECO:0000269PubMed:17028174, ECO:0000269PubMed:18663353}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18663353}. Note=Colocalizes with FLCN in the cytoplasm.

Disease Associations

Tissue Specificity

Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue. {ECO:0000269PubMed:17028174, ECO:0000269PubMed:18403135}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001932	regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0002327	immature B cell differentiation
GO:0002904	positive regulation of B cell apoptotic process
GO:0009267	cellular response to starvation
GO:0031929	TOR signaling
GO:0032007	negative regulation of TOR signaling
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:2000973	regulation of pro-B cell differentiation