Version 5.4
Homo sapiens Protein: TNPO3
Summary
InnateDB Protein IDBP-40523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNPO3
Protein Name transportin 3
Synonyms IPO12; LGMD1F; MTR10A; TRN-SR; TRN-SR2; TRNSR;
Species Homo sapiens
Ensembl Protein ENSP00000265388
InnateDB Gene IDBG-40521 (TNPO3)
Protein Structure
UniProt Annotation
Function Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. {ECO:0000269PubMed:10366588, ECO:0000269PubMed:10713112, ECO:0000269PubMed:11517331, ECO:0000269PubMed:12628928}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10713112}. Nucleus {ECO:0000269PubMed:10713112}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0035048 splicing factor protein import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR013598 Exportin-1/Importin-beta-like
IPR016024 Armadillo-type fold
PFAM PF08389
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5L0
PhosphoSite PhosphoSite-Q9Y5L0
TrEMBL E9PFH4
UniProt Splice Variant
Entrez Gene 23534
UniGene Hs.193613
RefSeq NP_036602
HUGO HGNC:17103
OMIM 610032
CCDS CCDS5809
HPRD 18209
IMGT
EMBL AC018639 AC025594 AF145029 AJ133769 AK022910 AK225999 BC009221 CH236950 CH471070
GenPept AAD38537 AAH09221 BAG51133 CAB42643 EAL24106 EAW83709 EAW83710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca