Version 5.4
Homo sapiens Gene: TNPO3
Summary
InnateDB Gene IDBG-40521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNPO3
Gene Name transportin 3
Synonyms IPO12; LGMD1F; MTR10A; TRN-SR; TRN-SR2; TRNSR
Species Homo sapiens
Ensembl Gene ENSG00000064419
Encoded Proteins
IDBP-40523
transportin 3
IDBP-474928
transportin 3
IDBP-483506
transportin 3
IDBP-481894
transportin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128954180-129055144
Strand Reverse strand
Band q32.1
Transcripts
ENST00000265388 ENSP00000265388
ENST00000482320 ENSP00000420089
ENST00000471234 ENSP00000418646
ENST00000471166 ENSP00000418267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0035048 splicing factor protein import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012535
View Gene Order
ENSBTAG00000004992
Not yet available
Cross-References
SwissProt
TrEMBL C9J7E5
UniProt Splice Variant
Entrez Gene 23534
UniGene Hs.193613
RefSeq NM_001191028 NM_012470
HUGO HGNC:17103
OMIM 610032
CCDS CCDS55162 CCDS5809
HPRD 18209
IMGT
EMBL AC018639 AC025594
GenPept
RNA Seq Atlas 23534

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca