Version 5.4
Homo sapiens Protein: ALKBH3
Summary
InnateDB Protein IDBP-40557.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALKBH3
Protein Name alkB, alkylation repair homolog 3 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302232
InnateDB Gene IDBG-40555 (ALKBH3)
Protein Structure
UniProt Annotation
Function Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:12594517, ECO:0000269PubMed:16174769, ECO:0000269PubMed:22055184}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:16174769, ECO:0000269PubMed:17979886}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
GO:0043734 DNA-N1-methyladenine dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0008283 cell proliferation
GO:0035552 oxidative single-stranded DNA demethylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
PFAM PF03171
PF13640
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96Q83
PhosphoSite PhosphoSite-Q96Q83
TrEMBL E9PRD0
UniProt Splice Variant
Entrez Gene 221120
UniGene Hs.720708
RefSeq NP_631917
HUGO HGNC:30141
OMIM 610603
CCDS CCDS7906
HPRD 16793
IMGT
EMBL AB042029 AC087521 BC015155 BC067257 BC103812 BC103813 BC103814 CH471064 DQ196343
GenPept AAH15155 AAH67257 AAI03813 AAI03814 AAI03815 ABA27096 BAB70508 EAW68078

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca