InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GZMB

Summary

InnateDB Protein

IDBP-4058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GZMB

Protein Name

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonyms

CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; HLP; SECT;

Species

Homo sapiens

Ensembl Protein

ENSP00000216341

InnateDB Gene

IDBG-4054 (GZMB)

Protein Structure

UniProt Annotation

Function

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Subcellular Localization

Cytoplasmic granule {ECO:0000269PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007219	Notch signaling pathway
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0019835	cytolysis
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030141	secretory granule
GO:0043231	intracellular membrane-bounded organelle