InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBED1

Summary

InnateDB Protein

IDBP-40621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBED1

Protein Name

zinc finger, BED-type containing 1

Synonyms

ALTE; DREF; hDREF; TRAMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000370616

InnateDB Gene

IDBG-232096 (ZBED1)

Protein Structure

UniProt Annotation

Function

Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity. {ECO:0000269PubMed:12663651}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12663651}. Note=In granular structures.

Disease Associations

Tissue Specificity

Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004803	transposase activity
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity