InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIRPA

Summary

InnateDB Protein

IDBP-40696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRPA

Protein Name

signal-regulatory protein alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348307

InnateDB Gene

IDBG-40694 (SIRPA)

Protein Structure

UniProt Annotation

Function

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269PubMed:10469599, ECO:0000269PubMed:11509594}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P78324