Version 5.4
| Homo sapiens Gene: SIRPA | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-40694.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | SIRPA | ||||||||||||||||||||||
| Gene Name | signal-regulatory protein alpha | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000198053 | ||||||||||||||||||||||
| Encoded Proteins |
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
SIRPA negatively regulates TLR4 or TLR3 dependent cytokine production through inhibition of NF-kappaB dependent signalling.
SIRPA down-regulation is lipopolysaccharide (LPS) inducible and contributes to innate immune activation in macrophages.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 20:1894167-1940592 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | p13 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
IL1 pathway
IL6 pathway
Prolactin pathway
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| REACTOME |
Cell surface interactions at the vascular wall pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
Hemostasis pathway
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| KEGG |
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | P78324 | ||||||||||||||||||||||
| TrEMBL | B4DP97 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 140885 | ||||||||||||||||||||||
| UniGene | Hs.581021 Hs.743876 | ||||||||||||||||||||||
| RefSeq | NM_001040022 NM_001040023 NM_080792 XM_005260669 XM_005260670 | ||||||||||||||||||||||
| HUGO | HGNC:9662 | ||||||||||||||||||||||
| OMIM | 602461 | ||||||||||||||||||||||
| CCDS | CCDS13022 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AB023430 AK290776 AK298243 AK312521 AL034562 AL117335 BC026692 BC033092 BC038510 BC075849 D86043 Y10375 Y11047 | ||||||||||||||||||||||
| GenPept | AAH26692 AAH33092 AAH38510 AAH75849 BAA12974 BAA87929 BAF83465 BAG35420 BAG60509 CAA71403 CAA71944 CAB38874 CAC12723 CAM28287 CAM28335 | ||||||||||||||||||||||
| RNA Seq Atlas | 140885 | ||||||||||||||||||||||