Homo sapiens Protein: EXT2 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-40704.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | EXT2 | ||||||||||||||||||||||
Protein Name | exostosin 2 | ||||||||||||||||||||||
Synonyms | SOTV; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000342656 | ||||||||||||||||||||||
InnateDB Gene | IDBG-40702 (EXT2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. | ||||||||||||||||||||||
Subcellular Localization | Endoplasmic reticulum membrane {ECO:0000269PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269PubMed:10679296}. Golgi apparatus membrane {ECO:0000269PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. | ||||||||||||||||||||||
Disease Associations | Hereditary multiple exostoses 2 (EXT2) [MIM:133701]: EXT is a genetically heterogeneous bone disorder caused by genes segregating on human chromosomes 8, 11, and 19 and designated EXT1, EXT2 and EXT3 respectively. EXT is a dominantly inherited skeletal disorder primarily affecting endochondral bone during growth. The disease is characterized by formation of numerous cartilage-capped, benign bone tumors (osteocartilaginous exostoses or osteochondromas) that are often accompanied by skeletal deformities and short stature. In a small percentage of cases exostoses have exhibited malignant transformation resulting in an osteosarcoma or chondrosarcoma. Osteochondromas development can also occur as a sporadic event. {ECO:0000269PubMed:10429361, ECO:0000269PubMed:10480354, ECO:0000269PubMed:10738008, ECO:0000269PubMed:11169766, ECO:0000269PubMed:11170095, ECO:0000269PubMed:11432960, ECO:0000269PubMed:11668521, ECO:0000269PubMed:9326317}. Note=The disease is caused by mutations affecting the gene represented in this entry.Potocki-Shaffer syndrome (POSHS) [MIM:601224]: A syndrome characterized by foramina parietalia permagna, multiple exostoses, and craniofacial dysostosis and mental retardation in some cases. Note=The gene represented in this entry is involved in disease pathogenesis. | ||||||||||||||||||||||
Tissue Specificity | Ubiquitous. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR004263
Exostosin-like IPR015338 EXTL2, alpha-1,4-N-acetylhexosaminyltransferase IPR029044 Nucleotide-diphospho-sugar transferases |
||||||||||||||||||||||
PFAM |
PF03016
PF09258 |
||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART | |||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q93063 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q93063 | ||||||||||||||||||||||
TrEMBL | E9PNL9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 2132 | ||||||||||||||||||||||
UniGene | Hs.625019 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:3513 | ||||||||||||||||||||||
OMIM | 608210 | ||||||||||||||||||||||
CCDS | CCDS7908 | ||||||||||||||||||||||
HPRD | 00599 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC068457 AC103854 AC134775 AK312375 BC010058 BX648142 CH471064 U62740 U64511 U67356 U67357 U67358 U67360 U67361 U67362 U67363 U67364 U67365 U67366 U67367 U67368 U72263 | ||||||||||||||||||||||
GenPept | AAB07008 AAB62718 AAC50764 AAC51219 AAH10058 BAG35293 EAW68068 EAW68070 EAW68071 | ||||||||||||||||||||||