InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSL6

Summary

InnateDB Protein

IDBP-40762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL6

Protein Name

acyl-CoA synthetase long-chain family member 6

Synonyms

ACS2; FACL6; LACS 6; LACS2; LACS5;

Species

Homo sapiens

Ensembl Protein

ENSP00000368566

InnateDB Gene

IDBG-40756 (ACSL6)

Protein Structure

UniProt Annotation

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.Note=A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6.Note=A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6.

Tissue Specificity

Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain. {ECO:0000269PubMed:10548543}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001676	long-chain fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006641	triglyceride metabolic process
GO:0007405	neuroblast proliferation
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0009629	response to gravity
GO:0010747	positive regulation of plasma membrane long-chain fatty acid transport
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010976	positive regulation of neuron projection development
GO:0015908	fatty acid transport
GO:0019432	triglyceride biosynthetic process
GO:0032869	cellular response to insulin stimulus
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0048545	response to steroid hormone
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane