InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACSL6

Summary

InnateDB Gene

IDBG-40756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL6

Gene Name

acyl-CoA synthetase long-chain family member 6

Synonyms

ACS2; FACL6; LACS 6; LACS2; LACS5

Species

Homo sapiens

Ensembl Gene

ENSG00000164398

Encoded Proteins

IDBP-40758

acyl-CoA synthetase long-chain family member 6

IDBP-40762

acyl-CoA synthetase long-chain family member 6

IDBP-40764

acyl-CoA synthetase long-chain family member 6

IDBP-40766

acyl-CoA synthetase long-chain family member 6

IDBP-40770

acyl-CoA synthetase long-chain family member 6

IDBP-40772

acyl-CoA synthetase long-chain family member 6

IDBP-40774

acyl-CoA synthetase long-chain family member 6

IDBP-376085

acyl-CoA synthetase long-chain family member 6

IDBP-376108

acyl-CoA synthetase long-chain family member 6

IDBP-376113

acyl-CoA synthetase long-chain family member 6

IDBP-376119

acyl-CoA synthetase long-chain family member 6

IDBP-376125

acyl-CoA synthetase long-chain family member 6

IDBP-376130

acyl-CoA synthetase long-chain family member 6

IDBP-376132

acyl-CoA synthetase long-chain family member 6

IDBP-376136

acyl-CoA synthetase long-chain family member 6

IDBP-600888

acyl-CoA synthetase long-chain family member 6

IDBP-808486

acyl-CoA synthetase long-chain family member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:131806990-132012243

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000296869	ENSP00000296869
ENST00000379264	ENSP00000368566
ENST00000357096	ENSP00000349608
ENST00000379255	ENSP00000368557
ENST00000379246	ENSP00000368548
ENST00000379244	ENSP00000368546
ENST00000379240	ENSP00000368542
ENST00000413683	ENSP00000415140
ENST00000431707	ENSP00000413329
ENST00000434099	ENSP00000397507
ENST00000430403	ENSP00000398423
ENST00000419502	ENSP00000388424
ENST00000416557	ENSP00000398381
ENST00000414078	ENSP00000394810
ENST00000441995	ENSP00000389189
ENST00000493861
ENST00000492156
ENST00000484870
ENST00000489047
ENST00000477640
ENST00000469164
ENST00000543479	ENSP00000442124
ENST00000616644	ENSP00000481155

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001676	long-chain fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006641	triglyceride metabolic process
GO:0007405	neuroblast proliferation
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0009629	response to gravity
GO:0010747	positive regulation of plasma membrane long-chain fatty acid transport
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010976	positive regulation of neuron projection development
GO:0015908	fatty acid transport
GO:0019432	triglyceride biosynthetic process
GO:0032869	cellular response to insulin stimulus
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0048545	response to steroid hormone
GO:0048666	neuron development

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020333

View Gene Order

ENSBTAG00000019708

Not yet available

Pathways

NETPATH

REACTOME

REACT_380

Synthesis of very long-chain fatty acyl-CoAs pathway

REACT_1319

Fatty Acyl-CoA Biosynthesis pathway

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00061

Fatty acid biosynthesis pathway

hsa00071

Fatty acid degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.14945

RefSeq

NM_001009185 NM_001205247 NM_001205248 NM_001205250 NM_001205251 NM_001278059 NM_015256 XM_006714579 XM_006714580 XM_006714581

HUGO

OMIM

CCDS

CCDS34228 CCDS34229 CCDS56381 CCDS56382 CCDS56383 CCDS75292

HPRD

09190

IMGT

EMBL

GenPept

RNA Seq Atlas