InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMAN1

Summary

InnateDB Protein

IDBP-4086.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMAN1

Protein Name

lectin, mannose-binding, 1

Synonyms

ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; MCFD1; MR60;

Species

Homo sapiens

Ensembl Protein

ENSP00000251047

InnateDB Gene

IDBG-4084 (LMAN1)

Protein Structure

UniProt Annotation

Function

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. {ECO:0000269PubMed:12717434, ECO:0000269PubMed:13130098}.

Subcellular Localization

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Disease Associations

Factor V and factor VIII combined deficiency 1 (F5F8D1) [MIM:227300]: A blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal. {ECO:0000269PubMed:10090935}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:13130098}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005537	mannose binding
GO:0046872	metal ion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007029	endoplasmic reticulum organization
GO:0007030	Golgi organization
GO:0007596	blood coagulation
GO:0010638	positive regulation of organelle organization
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030017	sarcomere
GO:0030134	ER to Golgi transport vesicle
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome