InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS28

Summary

InnateDB Protein

IDBP-40911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS28

Protein Name

vacuolar protein sorting 28 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292510

InnateDB Gene

IDBG-40909 (VPS28)

Protein Structure

UniProt Annotation

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269PubMed:11916981}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11916981}. Late endosome membrane {ECO:0000269PubMed:11916981}; Peripheral membrane protein {ECO:0000269PubMed:11916981}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0031397	negative regulation of protein ubiquitination
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0061024	membrane organization
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000813	ESCRT I complex
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome