InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDYN

Summary

InnateDB Protein

IDBP-40919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDYN

Protein Name

prodynorphin

Synonyms

ADCA; PENKB; SCA23;

Species

Homo sapiens

Ensembl Protein

ENSP00000217305

InnateDB Gene

IDBG-40917 (PDYN)

Protein Structure

UniProt Annotation

Function

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). {ECO:0000250}.Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.Leumorphin has a typical opiod activity and may have anti-apoptotic effect. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Spinocerebellar ataxia 23 (SCA23) [MIM:610245]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. {ECO:0000269PubMed:21035104}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.