Homo sapiens Gene: PDYN
Summary
InnateDB Gene IDBG-40917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDYN
Gene Name prodynorphin
Synonyms ADCA; PENKB; SCA23
Species Homo sapiens
Ensembl Gene ENSG00000101327
Encoded Proteins
prodynorphin
prodynorphin
prodynorphin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:1978757-1994285
Strand Reverse strand
Band p13
Transcripts
ENST00000217305 ENSP00000217305
ENST00000539905 ENSP00000440185
ENST00000540134 ENSP00000442259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0008219 cell death
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (i) signalling events pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
G-protein activation pathway
Opioid Signalling pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.22584
RefSeq NM_001190892 NM_001190898 NM_001190899 NM_001190900 NM_024411
HUGO
OMIM
CCDS CCDS13023
HPRD 08838
IMGT
EMBL
GenPept
RNA Seq Atlas