InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAT

Summary

InnateDB Protein

IDBP-41004.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAT

Protein Name

tyrosine aminotransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348234

InnateDB Gene

IDBG-41002 (TAT)

Protein Structure

UniProt Annotation

Function

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. {ECO:0000269PubMed:16640556, ECO:0000269PubMed:7999802}.

Subcellular Localization

Disease Associations

Tyrosinemia 2 (TYRSN2) [MIM:276600]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. {ECO:0000269PubMed:1357662}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0006536	glutamate metabolic process
GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006979	response to oxidative stress
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009072	aromatic amino acid family metabolic process
GO:0009074	aromatic amino acid family catabolic process
GO:0014070	response to organic cyclic compound
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046689	response to mercury ion
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005575	cellular_component
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase
IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR004839 Aminotransferase, class I/classII
IPR005957 Tyrosine aminotransferase
IPR005958 Tyrosine/nicotianamine aminotransferase
IPR011715 Tyrosine aminotransferase ubiquitination region
IPR015424 Pyridoxal phosphate-dependent transferase
IPR021178 Tyrosine transaminase

PFAM

PF00266
PF01041
PF01212
PF00155
PF07706

PRINTS

PIRSF

PIRSF000390
PIRSF000517

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17735