InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAT

Summary

InnateDB Gene

IDBG-41002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAT

Gene Name

tyrosine aminotransferase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000198650

Encoded Proteins

IDBP-41004

tyrosine aminotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:71565660-71577130

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000355962	ENSP00000348234
ENST00000564007
ENST00000566094
ENST00000566010

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0006536	glutamate metabolic process
GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0006979	response to oxidative stress
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009072	aromatic amino acid family metabolic process
GO:0009074	aromatic amino acid family catabolic process
GO:0014070	response to organic cyclic compound
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046689	response to mercury ion
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005575	cellular_component
GO:0005739	mitochondrion
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001670

View Gene Order

ENSBTAG00000002214

Not yet available

Pathways

NETPATH

REACTOME

REACT_1786

Phenylalanine and tyrosine catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00360

Phenylalanine metabolism pathway

hsa00400

Phenylalanine, tyrosine and tryptophan biosynthesis pathway

hsa00130

Ubiquinone and other terpenoid-quinone biosynthesis pathway

hsa00350

Tyrosine metabolism pathway

hsa00270

Cysteine and methionine metabolism pathway

INOH

INOH website

Phenylalanine degradation pathway

INOH website

Tyrosine metabolism pathway

PID NCI

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.161640 Hs.598179

RefSeq

NM_000353

HUGO

OMIM

CCDS

CCDS10903

HPRD

11776

IMGT

EMBL

GenPept

RNA Seq Atlas