InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDFIP2

Summary

InnateDB Protein

IDBP-41125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDFIP2

Protein Name

Nedd4 family interacting protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000218652

InnateDB Gene

IDBG-41123 (NDFIP2)

Protein Structure

UniProt Annotation

Function

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling. {ECO:0000269PubMed:12761501, ECO:0000269PubMed:19343052, ECO:0000269PubMed:20534535}.

Subcellular Localization

Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.

Disease Associations

Tissue Specificity

Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269PubMed:12796489}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0050699	WW domain binding

Biological Process

GO:0007165	signal transduction
GO:0010629	negative regulation of gene expression
GO:0031398	positive regulation of protein ubiquitination
GO:0032410	negative regulation of transporter activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051224	negative regulation of protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0032585	multivesicular body membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm