InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPK8IP1

Summary

InnateDB Protein

IDBP-41202.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK8IP1

Protein Name

mitogen-activated protein kinase 8 interacting protein 1

Synonyms

IB1; JIP-1; JIP1; PRKM8IP;

Species

Homo sapiens

Ensembl Protein

ENSP00000241014

InnateDB Gene

IDBG-41200 (MAPK8IP1)

Protein Structure

UniProt Annotation

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.

Disease Associations

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:10700186}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0008432	JUN kinase binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007258	JUN phosphorylation
GO:0009967	positive regulation of signal transduction
GO:0016192	vesicle-mediated transport
GO:0043066	negative regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0046328	regulation of JNK cascade
GO:0046329	negative regulation of JNK cascade
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031966	mitochondrial membrane
GO:0043005	neuron projection
GO:0044294	dendritic growth cone
GO:0044295	axonal growth cone
GO:0044297	cell body
GO:0044302	dentate gyrus mossy fiber
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm