InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAPK8IP1

Summary

InnateDB Gene

IDBG-41200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK8IP1

Gene Name

mitogen-activated protein kinase 8 interacting protein 1

Synonyms

IB1; JIP-1; JIP1; PRKM8IP

Species

Homo sapiens

Ensembl Gene

ENSG00000121653

Encoded Proteins

IDBP-41202

mitogen-activated protein kinase 8 interacting protein 1

IDBP-239166

mitogen-activated protein kinase 8 interacting protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:45885651-45906465

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000241014	ENSP00000241014
ENST00000395629	ENSP00000378991
ENST00000497090

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0008432	JUN kinase binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042802	identical protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007258	JUN phosphorylation
GO:0009967	positive regulation of signal transduction
GO:0016192	vesicle-mediated transport
GO:0043066	negative regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0046328	regulation of JNK cascade
GO:0046329	negative regulation of JNK cascade
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031966	mitochondrial membrane
GO:0043005	neuron projection
GO:0044294	dendritic growth cone
GO:0044295	axonal growth cone
GO:0044297	cell body
GO:0044302	dentate gyrus mossy fiber
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027223

View Gene Order

ENSBTAG00000000317

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q9UQF2

TrEMBL

B4DJ64 E9PBB9 Q59EU1

UniProt Splice Variant

Entrez Gene

9479

UniGene

Hs.234249

RefSeq

NM_005456 XM_005253226

HUGO

HGNC:6882

OMIM

604641

CCDS

CCDS7916

HPRD

IMGT

EMBL

AB209720 AC068385 AF007134 AF074091 AK295942 CH471064

GenPept

AAC19150 AAD20443 BAD92957 BAG58726 EAW68027 EAW68028

RNA Seq Atlas

9479