InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXW7

Summary

InnateDB Protein

IDBP-41237.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW7

Protein Name

F-box and WD repeat domain containing 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263981

InnateDB Gene

IDBG-41233 (FBXW7)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. {ECO:0000269PubMed:11565034, ECO:0000269PubMed:11585921, ECO:0000269PubMed:15103331, ECO:0000269PubMed:17558397, ECO:0000269PubMed:17873522}.

Subcellular Localization

Isoform 1: Nucleus, nucleoplasm.Isoform 2: Cytoplasm.Isoform 4: Nucleus, nucleolus.Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is widely expressed. Isoform 4 is expressed in brain. {ECO:0000269PubMed:12354302}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	124 [view]
Protein-Protein	123 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001944	vasculature development
GO:0006974	cellular response to DNA damage stimulus
GO:0007062	sister chromatid cohesion
GO:0007219	Notch signaling pathway
GO:0010868	negative regulation of triglyceride biosynthetic process
GO:0010883	regulation of lipid storage
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032876	negative regulation of DNA endoreduplication
GO:0032880	regulation of protein localization
GO:0034644	cellular response to UV
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045746	negative regulation of Notch signaling pathway
GO:0050821	protein stabilization
GO:0055088	lipid homeostasis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000346	negative regulation of hepatocyte proliferation
GO:2000639	negative regulation of SREBP signaling pathway