InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSF2

Summary

InnateDB Protein

IDBP-41279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF2

Protein Name

colony stimulating factor 2 (granulocyte-macrophage)

Synonyms

GMCSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000296871

InnateDB Gene

IDBG-41275 (CSF2)

Protein Structure

UniProt Annotation

Function

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	9 [view]
Protein-DNA	23 [view]
Protein-RNA	12 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005129	granulocyte macrophage colony-stimulating factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001892	embryonic placenta development
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0032747	positive regulation of interleukin-23 production
GO:0042045	epithelial fluid transport
GO:0042116	macrophage activation
GO:0042127	regulation of cell proliferation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043011	myeloid dendritic cell differentiation
GO:0045740	positive regulation of DNA replication
GO:0045918	negative regulation of cytolysis
GO:0071222	cellular response to lipopolysaccharide
GO:0071803	positive regulation of podosome assembly
GO:0097028	dendritic cell differentiation
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand