InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSF2

Summary

InnateDB Gene

IDBG-41275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF2

Gene Name

colony stimulating factor 2 (granulocyte-macrophage)

Synonyms

GMCSF

Species

Homo sapiens

Ensembl Gene

ENSG00000164400

Encoded Proteins

IDBP-41279

colony stimulating factor 2 (granulocyte-macrophage)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23453633

[Mus musculus] CSF2 is a negative regulator of IL21-mediated apoptosis in conventional dendritic cells.

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:132073790-132076170

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000296871

ENSP00000296871

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	9 [view]
Protein-DNA	23 [view]
Protein-RNA	12 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005129	granulocyte macrophage colony-stimulating factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001892	embryonic placenta development
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0032747	positive regulation of interleukin-23 production
GO:0042045	epithelial fluid transport
GO:0042116	macrophage activation
GO:0042127	regulation of cell proliferation
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043011	myeloid dendritic cell differentiation
GO:0045740	positive regulation of DNA replication
GO:0045918	negative regulation of cytolysis
GO:0071222	cellular response to lipopolysaccharide
GO:0071803	positive regulation of podosome assembly
GO:0097028	dendritic cell differentiation
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand