InnateDB Protein
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IDBP-41282.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLB1
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Protein Name
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phospholipase B1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000330442
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InnateDB Gene
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IDBG-41280 (PLB1)
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Protein Structure
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Function |
Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). {ECO:0000250}.
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Subcellular Localization |
Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Present in the intestinal brush border membranes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the epidermis (at protein level). {ECO:0000269PubMed:12150957}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001087
Lipase, GDSL
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PFAM |
PF00657
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P1J6
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PhosphoSite |
PhosphoSite-Q6P1J6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
151056
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UniGene |
Hs.444933
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RefSeq |
NP_694566
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HUGO |
HGNC:30041
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OMIM |
610179
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CCDS |
CCDS33168
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HPRD |
15141
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IMGT |
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EMBL |
AC074011
AC093164
AK055428
BC042674
BC065041
BC153864
CH471053
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GenPept |
AAH42674
AAH65041
AAI53865
AAY24081
AAY24082
BAB70920
EAX00532
EAX00533
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