InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IST1

Summary

InnateDB Protein

IDBP-41289.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IST1

Protein Name

increased sodium tolerance 1 homolog (yeast)

Synonyms

OLC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000330408

InnateDB Gene

IDBG-41285 (IST1)

Protein Structure

UniProt Annotation

Function

Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. {ECO:0000269PubMed:19129479, ECO:0000269PubMed:19129480}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000269PubMed:19129479, ECO:0000269PubMed:19129480}. Note=Localizes to the midbody of dividing cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0090541	MIT domain binding

Biological Process

GO:0000910	cytokinesis
GO:0008104	protein localization
GO:0009838	abscission
GO:0019076	viral release from host cell
GO:0045184	establishment of protein localization
GO:0045862	positive regulation of proteolysis
GO:0046745	viral capsid secondary envelopment
GO:0051301	cell division

Cellular Component

GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome
GO:0090543	Flemming body