Version 5.4
Homo sapiens Protein: PDE12
Summary
InnateDB Protein IDBP-41302.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE12
Protein Name phosphodiesterase 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000309142
InnateDB Gene IDBG-41300 (PDE12)
Protein Structure
UniProt Annotation
Function Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. {ECO:0000269PubMed:15231837, ECO:0000269PubMed:21245038, ECO:0000269PubMed:21666256, ECO:0000269PubMed:22285541}.
Subcellular Localization Mitochondrion matrix {ECO:0000269PubMed:21245038, ECO:0000269PubMed:21666256, ECO:0000269PubMed:22285541}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:15231837}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0045087 innate immune response (InnateDB)
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6L8Q7
PhosphoSite PhosphoSite-Q6L8Q7
TrEMBL
UniProt Splice Variant
Entrez Gene 201626
UniGene Hs.572993
RefSeq NP_808881
HUGO HGNC:25386
OMIM
CCDS CCDS33772
HPRD 11842
IMGT
EMBL AB115695 AK074423 AK300374 AL831824 CH471055
GenPept BAB85079 BAD20938 BAG62110 CAD38538 EAW65342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca