InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF675

Summary

InnateDB Protein

IDBP-41465.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF675

Protein Name

zinc finger protein 675

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352836

InnateDB Gene

IDBG-41463 (ZNF675)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0043508	negative regulation of JUN kinase activity
GO:0045453	bone resorption
GO:0045671	negative regulation of osteoclast differentiation
GO:0046329	negative regulation of JNK cascade
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway
GO:2000678	negative regulation of transcription regulatory region DNA binding