Version 5.4
Homo sapiens Protein: HPR
Summary
InnateDB Protein IDBP-41490.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPR
Protein Name haptoglobin
Synonyms A-259H10.2; HP;
Species Homo sapiens
Ensembl Protein ENSP00000349451
InnateDB Gene IDBG-720810 (HPR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines. {ECO:0000269PubMed:8945641}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0030492 hemoglobin binding
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0034366 spherical high-density lipoprotein particle
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00739
PhosphoSite PhosphoSite-P00739
TrEMBL Q14552
UniProt Splice Variant
Entrez Gene 3250
UniGene Hs.655361
RefSeq
HUGO HGNC:5156
OMIM 140210
CCDS
HPRD 00773
IMGT
EMBL AC004682 AC009087 K03431 M10935 M13908 M69197 X01787 X01788 X01790 X01792 X01794 X89214
GenPept AAA52686 AAA88079 AAA88081 AAC27433 CAA25927 CAA61501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca