Version 5.4
Homo sapiens Gene: HPR
Summary
InnateDB Gene IDBG-720810.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPR
Gene Name haptoglobin-related protein
Synonyms A-259H10.2; HP
Species Homo sapiens
Ensembl Gene ENSG00000261701
Encoded Proteins
IDBP-41490
haptoglobin
IDBP-41569
haptoglobin
IDBP-595052
haptoglobin
IDBP-748604
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22156194
[Mus musculus] Haptoglobin activates innate immunity to enhance acute transplant rejection.
Entrez Gene
Summary This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:72063224-72077246
Strand Forward strand
Band q22.2
Transcripts
ENST00000356967 ENSP00000349451
ENST00000228226 ENSP00000228226
ENST00000540303 ENSP00000441828
ENST00000566168
ENST00000561690 ENSP00000462916
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0030492 hemoglobin binding
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0034366 spherical high-density lipoprotein particle
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000031722
View Gene Order
Pathways
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655361
RefSeq NM_001126102 NM_005143 XM_005255922 NM_020995 XM_006721186
HUGO
OMIM
CCDS CCDS45524 CCDS45525 CCDS42193
HPRD 00773
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca