InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UNC45B

Summary

InnateDB Protein

IDBP-41500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC45B

Protein Name

unc-45 homolog B (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000268876

InnateDB Gene

IDBG-41498 (UNC45B)

Protein Structure

UniProt Annotation

Function

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0007517	muscle organ development
GO:0030154	cell differentiation
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR013026 Tetratricopeptide repeat-containing domain
IPR016024 Armadillo-type fold
IPR019734 Tetratricopeptide repeat
IPR024660 UNC-45/Ring assembly protein 3

PFAM

PF00514
PF13174
PF13176
PF13181
PF11701

PRINTS

PIRSF

SMART

SM00185
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IWX7