InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM2

Summary

InnateDB Protein

IDBP-41618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM2

Protein Name

tripartite motif containing 2

Synonyms

CMT2R; RNF86;

Species

Homo sapiens

Ensembl Protein

ENSP00000339659

InnateDB Gene

IDBG-41616 (TRIM2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008219	cell death
GO:0016567	protein ubiquitination
GO:0043523	regulation of neuron apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001298 Filamin/ABP280 repeat
IPR001841 Zinc finger, RING-type
IPR003649 B-box, C-terminal
IPR013017 NHL repeat, subgroup
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF01436
PF13639
PF14634
PF00630
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00557
SM00184
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C040