Version 5.4
Homo sapiens Protein: ATG13
Summary
InnateDB Protein IDBP-41856.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG13
Protein Name ATG13 autophagy related 13 homolog (S. cerevisiae)
Synonyms KIAA0652; PARATARG8;
Species Homo sapiens
Ensembl Protein ENSP00000352500
InnateDB Gene IDBG-41852 (ATG13)
Protein Structure
UniProt Annotation
Function Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269PubMed:18936157, ECO:0000269PubMed:19211835, ECO:0000269PubMed:19225151, ECO:0000269PubMed:19287211, ECO:0000269PubMed:21795849, ECO:0000269PubMed:21855797}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000045 autophagic vacuole assembly
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005829 cytosol
GO:0034273 ATG1/UKL1 signaling complex
GO:0070969 ULK1-ATG13-FIP200 complex
Protein Structure and Domains
PDB ID
InterPro IPR018731 Autophagy-related protein 13
PFAM PF10033
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75143
PhosphoSite PhosphoSite-O75143
TrEMBL J9JIF6
UniProt Splice Variant
Entrez Gene 9776
UniGene
RefSeq NP_001192049
HUGO HGNC:29091
OMIM 615088
CCDS CCDS44582
HPRD 13809
IMGT
EMBL AB014552 AC115088 AC127035 AK023867 AK223603 AK294110 BC001331 BC002378 BC006191 CH471064
GenPept AAH01331 AAH02378 AAH06191 BAA31627 BAB14707 BAD97323 BAG57445 EAW67985 EAW67986 EAW67987 EAW67988 EAW67989 EAW67990 EAW67991

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca