InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKR1B1

Summary

InnateDB Protein

IDBP-42172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1B1

Protein Name

aldo-keto reductase family 1, member B1 (aldose reductase)

Synonyms

ADR; ALDR1; ALR2; AR;

Species

Homo sapiens

Ensembl Protein

ENSP00000285930

InnateDB Gene

IDBG-42170 (AKR1B1)

Protein Structure

UniProt Annotation

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269PubMed:8435445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0004033	aldo-keto reductase (NADP) activity
GO:0009055	electron carrier activity
GO:0043795	glyceraldehyde oxidoreductase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0006950	response to stress
GO:0008202	steroid metabolic process
GO:0044281	small molecule metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0055114	oxidation-reduction process