InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AKR1B1

Summary

InnateDB Gene

IDBG-42170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1B1

Gene Name

aldo-keto reductase family 1, member B1 (aldose reductase)

Synonyms

ADR; ALDR1; ALR2; AR

Species

Homo sapiens

Ensembl Gene

ENSG00000085662

Encoded Proteins

IDBP-42172

aldo-keto reductase family 1, member B1 (aldose reductase)

IDBP-386440

aldo-keto reductase family 1, member B1 (aldose reductase)

IDBP-386442

aldo-keto reductase family 1, member B1 (aldose reductase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:134442350-134459284

Strand

Reverse strand

Band

q33

Transcripts

ENST00000285930	ENSP00000285930
ENST00000434222	ENSP00000414399
ENST00000426422	ENSP00000413205
ENST00000465351
ENST00000467251
ENST00000498771
ENST00000498373
ENST00000487438
ENST00000489022
ENST00000491741
ENST00000497983
ENST00000484592
ENST00000467829
ENST00000462784

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0004033	aldo-keto reductase (NADP) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0043795	glyceraldehyde oxidoreductase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0006950	response to stress
GO:0008202	steroid metabolic process
GO:0044281	small molecule metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001642

View Gene Order

ENSBTAG00000009902

Not yet available

Pathways

NETPATH

REACTOME

REACT_11038

Pregnenolone biosynthesis pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_11057

Metabolism of steroid hormones and vitamin D pathway

REACT_111217

Metabolism pathway

KEGG

hsa00052

Galactose metabolism pathway

hsa00040

Pentose and glucuronate interconversions pathway

hsa00051

Fructose and mannose metabolism pathway

hsa00561

Glycerolipid metabolism pathway

INOH

INOH website

Fructose Mannose metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.521212 Hs.602524

RefSeq

NM_001628 XM_005250234

HUGO

OMIM

CCDS

CCDS5831

HPRD

00071

IMGT

EMBL

GenPept

RNA Seq Atlas