InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPY2R

Summary

InnateDB Protein

IDBP-42277.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPY2R

Protein Name

neuropeptide Y receptor Y2

Synonyms

NPY2-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000332591

InnateDB Gene

IDBG-42275 (NPY2R)

Protein Structure

UniProt Annotation

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0002793	positive regulation of peptide secretion
GO:0003151	outflow tract morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0007626	locomotory behavior
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031645	negative regulation of neurological system process
GO:0033603	positive regulation of dopamine secretion
GO:0045785	positive regulation of cell adhesion
GO:0045987	positive regulation of smooth muscle contraction
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046903	secretion
GO:0050805	negative regulation of synaptic transmission
GO:0051048	negative regulation of secretion
GO:0051930	regulation of sensory perception of pain
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:2000252	negative regulation of feeding behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001358 Neuropeptide Y2 receptor
IPR005395 Neuropeptide FF receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR01012
PR01014
PR01570

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49146