Version 5.4
Homo sapiens Protein: C19orf40
Summary
InnateDB Protein IDBP-42399.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C19orf40
Protein Name chromosome 19 open reading frame 40
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254262
InnateDB Gene IDBG-42397 (C19orf40)
Protein Structure
UniProt Annotation
Function Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. {ECO:0000269PubMed:17289582}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17289582}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0043240 Fanconi anaemia nuclear complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9BTP7
TrEMBL X6R368
UniProt Splice Variant
Entrez Gene 91442
UniGene Hs.579899
RefSeq
HUGO HGNC:28467
OMIM 610884
CCDS
HPRD 14547
IMGT
EMBL AC011449
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca