Version 5.4
Homo sapiens Protein: RHPN2
Summary
InnateDB Protein IDBP-42415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHPN2
Protein Name rhophilin, Rho GTPase binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254260
InnateDB Gene IDBG-42413 (RHPN2)
Protein Structure
UniProt Annotation
Function Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269PubMed:12221077}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:12473120}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver. {ECO:0000269PubMed:12221077, ECO:0000269PubMed:12473120}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR004328 BRO1 domain
IPR011072 HR1 rho-binding repeat
PFAM PF00595
PF13180
PF03097
PF02185
PRINTS
PIRSF
SMART SM00228
SM01041
SM00742
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUC4
PhosphoSite PhosphoSite-Q8IUC4
TrEMBL B4DUS7
UniProt Splice Variant
Entrez Gene 85415
UniGene Hs.630796
RefSeq NP_149094
HUGO HGNC:19974
OMIM
CCDS CCDS12427
HPRD 10192
IMGT
EMBL AC008521 AC011449 AC093069 AF268032 AF423421 AJ347750 AK095001 AK098246 AK126506 AK300775 AK315105 AL831950 BC036447
GenPept AAH36447 AAK58588 AAQ04062 BAC04471 BAG37565 BAG53600 BAG54339 BAG62439 CAC87939 CAD38597

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca