Version 5.4
Homo sapiens Protein: SOX21
Summary
InnateDB Protein IDBP-42487.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX21
Protein Name SRY (sex determining region Y)-box 21
Synonyms SOX25;
Species Homo sapiens
Ensembl Protein ENSP00000366144
InnateDB Gene IDBG-42485 (SOX21)
Protein Structure
UniProt Annotation
Function May play a role as an activator of transcription of OPRM1. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001942 hair follicle development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0042633 hair cycle
GO:0043588 skin development
GO:0048863 stem cell differentiation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000104 Antifreeze protein, type I
IPR009071 High mobility group box domain
IPR022097 Transcription factor SOX
PFAM PF00505
PF09011
PF12336
PRINTS PR00308
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y651
PhosphoSite PhosphoSite-Q9Y651
TrEMBL
UniProt Splice Variant
Entrez Gene 11166
UniGene Hs.187577
RefSeq NP_009015
HUGO HGNC:11197
OMIM 604974
CCDS CCDS9473
HPRD 16083
IMGT
EMBL AF107044 AL137061 CH471085 X65666 X71136
GenPept AAC95381 CAA46617 CAA50466 CAI14398 EAX08946

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca