Version 5.4
Homo sapiens Gene: SOX21
Summary
InnateDB Gene IDBG-42485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX21
Gene Name SRY (sex determining region Y)-box 21
Synonyms SOX25
Species Homo sapiens
Ensembl Gene ENSG00000125285
Encoded Proteins
IDBP-42487
SRY (sex determining region Y)-box 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50%% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:94709622-94712399
Strand Reverse strand
Band q32.1
Transcripts
ENST00000376945 ENSP00000366144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001942 hair follicle development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0042633 hair cycle
GO:0043588 skin development
GO:0048863 stem cell differentiation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000061517
View Gene Order
Cross-References
SwissProt Q9Y651
TrEMBL
UniProt Splice Variant
Entrez Gene 11166
UniGene Hs.187577
RefSeq NM_007084
HUGO HGNC:11197
OMIM 604974
CCDS CCDS9473
HPRD
IMGT
EMBL AF107044 AL137061 CH471085 X65666 X71136
GenPept AAC95381 CAA46617 CAA50466 CAI14398 EAX08946
RNA Seq Atlas 11166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca