InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCC4

Summary

InnateDB Protein

IDBP-42536.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC4

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Synonyms

MOAT-B; MOATB; MRP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000366084

InnateDB Gene

IDBG-42534 (ABCC4)

Protein Structure

UniProt Annotation

Function

May be an organic anion pump relevant to cellular detoxification.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0002576	platelet degranulation
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007596	blood coagulation
GO:0008150	biological_process
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0030168	platelet activation
GO:0042493	response to drug
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031088	platelet dense granule membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR009147 Cystic fibrosis transmembrane conductance regulator
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PR01851

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt