InnateDB Protein
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IDBP-4254.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PES1
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Protein Name
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pescadillo homolog 1, containing BRCT domain (zebrafish)
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Synonyms
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PES;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000334612
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InnateDB Gene
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IDBG-4252 (PES1)
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Protein Structure
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Function |
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03028, ECO:0000269PubMed:16738141, ECO:0000269PubMed:17189298, ECO:0000269PubMed:17353269}.
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Subcellular Localization |
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255HAMAP-Rule:MF_03028}.
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Disease Associations |
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Tissue Specificity |
Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000463
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maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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GO:0000466
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maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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GO:0006364
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rRNA processing
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GO:0008283
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cell proliferation
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GO:0042254
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ribosome biogenesis
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GO:0042273
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ribosomal large subunit biogenesis
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GO:0051726
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regulation of cell cycle
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Cellular Component |
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PDB ID |
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InterPro |
IPR001357
BRCT domain
IPR010613
Pescadillo
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PFAM |
PF00533
PF12738
PF06732
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PRINTS |
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PIRSF |
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SMART |
SM00292
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TIGRFAMs |
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Modification |
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SwissProt |
O00541
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PhosphoSite |
PhosphoSite-O00541
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23481
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UniGene |
Hs.517543
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RefSeq |
NP_001230154
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HUGO |
HGNC:8848
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OMIM |
605819
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CCDS |
CCDS58802
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HPRD |
05783
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IMGT |
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EMBL |
AC005006
BC032489
CR456539
U78310
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GenPept |
AAB61140
AAH32489
CAG30425
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