InnateDB Protein
|
IDBP-4256.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PES1
|
Protein Name
|
pescadillo homolog 1, containing BRCT domain (zebrafish)
|
Synonyms
|
PES;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000346725
|
InnateDB Gene
|
IDBG-4252 (PES1)
|
Protein Structure
|
|
Function |
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03028, ECO:0000269PubMed:16738141, ECO:0000269PubMed:17189298, ECO:0000269PubMed:17353269}.
|
Subcellular Localization |
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255HAMAP-Rule:MF_03028}.
|
Disease Associations |
|
Tissue Specificity |
Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
|
Protein-Protein |
21
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001357
BRCT domain
IPR010613
Pescadillo
|
PFAM |
PF00533
PF12738
PF06732
|
PRINTS |
|
PIRSF |
|
SMART |
SM00292
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O00541
|
PhosphoSite |
PhosphoSite-O00541
|
TrEMBL |
B3KXD6
|
UniProt Splice Variant |
|
Entrez Gene |
23481
|
UniGene |
Hs.517543
|
RefSeq |
NP_055118
|
HUGO |
HGNC:8848
|
OMIM |
605819
|
CCDS |
CCDS13880
|
HPRD |
05783
|
IMGT |
|
EMBL |
AB451380
AC005006
AK127185
AK315518
BC032489
CH471095
CR456539
U78310
|
GenPept |
AAB61140
AAH32489
BAG37899
BAG54448
BAG70194
CAG30425
EAW59904
EAW59905
EAW59906
|
|
|