InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST5

Summary

InnateDB Protein

IDBP-42574.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST5

Protein Name

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

Synonyms

glcNAc6ST-3; gn6st-3; hIGn6ST; I-GlcNAc-6-ST; I-GlcNAc6ST;

Species

Homo sapiens

Ensembl Protein

ENSP00000338783

InnateDB Gene

IDBG-42572 (CHST5)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. {ECO:0000269PubMed:10491328, ECO:0000269PubMed:11352640, ECO:0000269PubMed:12218059, ECO:0000269PubMed:12626414}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305PubMed:12855678}; Single-pass type II membrane protein {ECO:0000305PubMed:12855678}. Note=Golgi membrane, early secretory pathway.

Disease Associations

Tissue Specificity

Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas. {ECO:0000269PubMed:10491328, ECO:0000269PubMed:11017086, ECO:0000269PubMed:11352640, ECO:0000269PubMed:12107080, ECO:0000269PubMed:12626414}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006477	protein sulfation
GO:0006790	sulfur compound metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0044281	small molecule metabolic process