InnateDB Protein
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IDBP-42618.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMEM231
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Protein Name
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transmembrane protein 231
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000258173
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InnateDB Gene
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IDBG-42616 (TMEM231)
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Protein Structure
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Function |
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone. {ECO:0000250}.
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Disease Associations |
Joubert syndrome 20 (JBTS20) [MIM:614970]: A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. {ECO:0000269PubMed:23012439}. Note=The disease is caused by mutations affecting the gene represented in this entry.Meckel syndrome 11 (MKS11) [MIM:615397]: A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. {ECO:0000269PubMed:23349226}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019306
Transmembrane protein 231
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PFAM |
PF10149
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H6L2
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PhosphoSite |
PhosphoSite-Q9H6L2
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TrEMBL |
B7Z5I3
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UniProt Splice Variant |
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Entrez Gene |
79583
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UniGene |
Hs.156784
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RefSeq |
NP_001070886
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HUGO |
HGNC:37234
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OMIM |
614949
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CCDS |
CCDS45530
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HPRD |
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IMGT |
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EMBL |
AC009163
AC025287
AK025820
AK096650
AK290483
AK298994
AY358612
BC010609
BC016401
BC063677
CH471114
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GenPept |
AAH10609
AAH16401
AAH63677
AAQ88975
BAB15244
BAF83172
BAG53347
BAH12919
EAW95632
EAW95633
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