InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARS

Summary

InnateDB Protein

IDBP-42750.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARS

Protein Name

methionyl-tRNA synthetase

Synonyms

METRS; MRS; MTRNS; SPG70;

Species

Homo sapiens

Ensembl Protein

ENSP00000262027

InnateDB Gene

IDBG-42746 (MARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Infantile liver failure syndrome 2 (ILFS2) [MIM:615486]: A life-threatening disorder of hepatic function that manifests with liver failure in the first months of life. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, anemia, liver canalicular cholestasis, steatosis, and iron deposition. {ECO:0000269PubMed:24103465}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.

Experimentally validated
Total	47 [view]
Protein-Protein	45 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004825	methionine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006431	methionyl-tRNA aminoacylation
GO:0010467	gene expression

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000738 WHEP-TRS
IPR009068 S15/NS1, RNA-binding
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold
IPR014758 Methionyl-tRNA synthetase
IPR015413 Methionyl/Leucyl tRNA synthetase
IPR029038 Methionyl-tRNA synthetase, Zn-domain

PFAM

PF00458
PF13098
PF13192
PF13462
PF13905
PF09334

PRINTS

PR01041

PIRSF

SMART

SM00991

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt