Version 5.4
Homo sapiens Gene: MARS
Summary
InnateDB Gene IDBG-42746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARS
Gene Name methionyl-tRNA synthetase
Synonyms METRS; MRS; MTRNS; SPG70
Species Homo sapiens
Ensembl Gene ENSG00000166986
Encoded Proteins
IDBP-42750
methionyl-tRNA synthetase
IDBP-585886
methionyl-tRNA synthetase
IDBP-598525
methionyl-tRNA synthetase
IDBP-587084
methionyl-tRNA synthetase
IDBP-598846
methionyl-tRNA synthetase
IDBP-591371
methionyl-tRNA synthetase
IDBP-597388
methionyl-tRNA synthetase
IDBP-583236
methionyl-tRNA synthetase
IDBP-601186
methionyl-tRNA synthetase
IDBP-599221
methionyl-tRNA synthetase
IDBP-590123
methionyl-tRNA synthetase
IDBP-583639
methionyl-tRNA synthetase
IDBP-587547
methionyl-tRNA synthetase
IDBP-590118
methionyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57475445-57517569
Strand Forward strand
Band q13.3
Transcripts
ENST00000262027 ENSP00000262027
ENST00000447721
ENST00000549133
ENST00000537638 ENSP00000446168
ENST00000548674
ENST00000550449
ENST00000546481
ENST00000545888 ENSP00000439307
ENST00000547062
ENST00000548714
ENST00000551842
ENST00000553162
ENST00000547501 ENSP00000447145
ENST00000551431 ENSP00000446729
ENST00000549074 ENSP00000447258
ENST00000552007 ENSP00000448576
ENST00000551892 ENSP00000450018
ENST00000548146
ENST00000553123
ENST00000552371 ENSP00000447914
ENST00000549827
ENST00000548944 ENSP00000449071
ENST00000549603
ENST00000546971
ENST00000548630
ENST00000549048
ENST00000548202
ENST00000552914 ENSP00000449787
ENST00000551805
ENST00000547665 ENSP00000448910
ENST00000552499 ENSP00000447335
ENST00000551172 ENSP00000448378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 45 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
GO:0010467 gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040354
View Gene Order
ENSBTAG00000018405
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00450
Selenocompound metabolism pathway
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
INOH website
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632707 Hs.641576 Hs.697828
RefSeq NM_004990
HUGO
OMIM
CCDS CCDS8942
HPRD 08864
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca