InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKI

Summary

InnateDB Protein

IDBP-42998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKI

Protein Name

diacylglycerol kinase, iota

Synonyms

DGK-IOTA;

Species

Homo sapiens

Ensembl Protein

ENSP00000288490

InnateDB Gene

IDBG-42996 (DGKI)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017016	Ras GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0032317	regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity
GO:0046579	positive regulation of Ras protein signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002110 Ankyrin repeat
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR020683 Ankyrin repeat-containing domain

PFAM