InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DGKI

Summary

InnateDB Gene

IDBG-42996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKI

Gene Name

diacylglycerol kinase, iota

Synonyms

DGK-IOTA

Species

Homo sapiens

Ensembl Gene

ENSG00000157680

Encoded Proteins

IDBP-42998

diacylglycerol kinase, iota

IDBP-386636

diacylglycerol kinase, iota

IDBP-386638

diacylglycerol kinase, iota

IDBP-386640

diacylglycerol kinase, iota

IDBP-807348

diacylglycerol kinase, iota

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:137381037-137847092

Strand

Reverse strand

Band

q33

Transcripts

ENST00000288490	ENSP00000288490
ENST00000453654	ENSP00000392161
ENST00000424189	ENSP00000396078
ENST00000446122	ENSP00000399131
ENST00000494390
ENST00000477835
ENST00000486153
ENST00000497321
ENST00000460662
ENST00000470895
ENST00000483619
ENST00000475388
ENST00000614521	ENSP00000479053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017016	Ras GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0032317	regulation of Rap GTPase activity
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity
GO:0046579	positive regulation of Ras protein signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038665

View Gene Order

ENSBTAG00000019980

Not yet available

Pathways

NETPATH

REACTOME

REACT_2202

Effects of PIP2 hydrolysis pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14797

Signaling by GPCR pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_604

Hemostasis pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa00561

Glycerolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.242947 Hs.630580 Hs.737768

RefSeq

NM_004717

HUGO

OMIM

CCDS

CCDS5845

HPRD

07238

IMGT

EMBL

GenPept

RNA Seq Atlas