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InnateDB Protein
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IDBP-4301.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TFF3
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Protein Name
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trefoil factor 3 (intestinal)
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Synonyms
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ITF; P1B; TFI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000291525
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InnateDB Gene
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IDBG-4297 (TFF3)
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Protein Structure
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| Function |
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). {ECO:0000269PubMed:11694446}.
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| Subcellular Localization |
Secreted, extracellular space, extracellular matrix, apical lamina {ECO:0000269PubMed:8454642}.
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| Disease Associations |
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| Tissue Specificity |
Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. {ECO:0000269PubMed:8346203, ECO:0000269PubMed:8454642}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
4
[view]
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| Protein-Protein |
3
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
IPR000519
P-type trefoil
IPR017994
P-type trefoil, chordata
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| PFAM |
PF00088
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| PRINTS |
PR00680
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| PIRSF |
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| SMART |
SM00018
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
7033
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| UniGene |
Hs.612366
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| RefSeq |
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| HUGO |
HGNC:11757
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| OMIM |
600633
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| CCDS |
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| HPRD |
02797
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4