Homo sapiens Gene: TFF3
Summary
InnateDB Gene IDBG-4297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFF3
Gene Name trefoil factor 3 (intestinal)
Synonyms ITF; P1B; TFI
Species Homo sapiens
Ensembl Gene ENSG00000160180
Encoded Proteins
trefoil factor 3 (intestinal)
trefoil factor 3 (intestinal)
trefoil factor 3 (intestinal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42311667-42315651
Strand Reverse strand
Band q22.3
Transcripts
ENST00000291525 ENSP00000291525
ENST00000398431 ENSP00000381462
ENST00000518498 ENSP00000430690
ENST00000489676
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0007586 digestion
GO:0043434 response to peptide hormone
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
GO:0032579 apical lamina of hyaline layer
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
IL4-mediated signaling events
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.612366
RefSeq NM_003226
HUGO
OMIM
CCDS CCDS33565
HPRD 02797
IMGT
EMBL
GenPept
RNA Seq Atlas